Heterocyclic Chemistry in Oncology: Promising Agents and Novel Approaches

Heterocyclic Chemistry in Oncology: Promising Agents and Novel Approaches sheds light on the critical role of heterocyclic compounds in contemporary cancer drug discovery and development.

As cancer continues to pose a major global health challenge, the book highlights how diverse heterocyclic scaffolds are acting as powerful tools in the search for safer, more effective, and targeted anticancer therapies. By integrating concepts from medicinal chemistry, molecular oncology, computational biology, and pharmaceutical sciences, the book presents a multidisciplinary perspective on the design and development of novel anticancer agents.

The book covers the fundamental principles of heterocyclic chemistry and cancer biology before examining key classes of bioactive heterocycles, including pyrimidines, imidazoles, triazoles, quinolines, indoles, pyrazoles, thiazoles, and fused heterocyclic systems. It discusses their synthesis, biological evaluation, structure–activity relationships, molecular targets, and mechanisms of action. The text further explores emerging areas such as molecular docking, artificial intelligence-assisted drug discovery, nanotechnology-enabled drug delivery systems, targeted therapies, and kinase inhibitors, providing insights into the technologies transforming modern oncology research.

Combining synthetic, biological, and translational perspectives, the book critically evaluates current advances, challenges, and future opportunities in the development of heterocycle-based anticancer therapeutics. It serves as an important resource for understanding both established drug candidates and next-generation approaches in cancer treatment.

Key Features

-Detailed discussions on the role of major heterocyclic compounds and scaffolds in anticancer drug discovery and development.
-Integrated perspectives combining synthetic chemistry, biological evaluation, and structure–activity relationship studies.
-In-depth analysis of molecular targets, mechanisms of action, and targeted cancer therapies
-Discussions on current challenges and future directions in translating heterocyclic compounds into clinical applications

Readership:

Medicinal chemists, pharmaceutical scientists, researchers, academic faculty, and postgraduate students in medicinal chemistry, pharmaceutical chemistry, drug discovery, and cancer research.

Editor(s):

Smriti Dewangan
Amity Institute of Pharmacy
Amity University Chhattisgarh
Raipur, Chhattisgarh
India

Anchal Verma
Department of Pharmacology
Shri Rawatpura Sarkar Institute of Pharmacy
Chhattisgarh Swami Vivekanand Technical University
Kumhari, Chhattisgarh
India

Varsha Rawat
Department of Pharmaceutics
Shri Rawatpura Sarkar Institute of Pharmacy
Chhattisgarh Swami Vivekanand Technical University
Kumhari, Chhattisgarh
India

Contributor(s):

Alok Singh Thakur
Department of Chemistry
Shri Shankaracharya Institute of Pharmaceutical Sciences and Research, Shri Shankaracharya Professional University
Bhilai, Chhattisgarh
India

Anchal Verma
Department of Pharmacology
Shri Rawatpura Sarkar Institute of Pharmacy, Chhattisgarh Swami Vivekanand Technical University
Kumhari, Chhattisgarh
India

Anand Kumar
University Department of Pharmacy
Santgahira Guru University
Ambikapur, Chhattisgarh
India

Ankit Mishra
Faculty of Pharmacy
VNS Group of Institutions, Rajiv Gandhi Proudyogiki Vishwavidyalaya
Bhopal, Madhya Pradesh
India

Anju Daharia
Department of Chemistry
Kamla Institute of Pharmaceutical Sciences, Shri Shankaracharya Professional University
Bhilai, Chhattisgarh
India

Anup Kumar Patra
Department of Pharmaceutical Analysis
College of Pharmaceutical Sciences, Biju Patnaik University of Technology
Puri, Odisha
India

Aruna Ghose
Department of Pharmacology
School of Pharmaceutical Sciences, Siksha'o' Anushandhan Deemed to be University
Bhubaneswar, Odisha
India

Ashish Majumdar
Department of Pharmaceutical Sciences
Columbia Institute of Pharmacy, Chhattisgarh Swami Vivekanand Technical University
Raipur, Chhattisgarh
India

Biswa Mohan Sahoo
School of Pharmacy and Life Sciences
Centurion University of Technology & Management
Jatni, Odisha
India

Chhatrapal Patel
Department of Pharmacy
Guru Ghasidas Vishwavidyalaya
Bilaspur, Chhattisgarh
India

Deepa Iyer
M.P. Council of Science and Technology, Vigyan Bhawan
Bhopal, Madhya Pradesh
India

Dipthi Shree
Department of Pharmaceutics
Roland Institute of Pharmaceutical Sciences
Berhampur, Odisha
India

Disha Kesharwani
Columbia Institute of Pharmacy, Chhattisgarh Swami Vivekanand Technical University
Raipur, Chhattisgarh
India

Deepika Singh
Nanomedicine and Bioengineering Research Laboratory, Department of Pharmacy
Indira Gandhi National tribal University
Amarkantak, Madhya Pradesh
India

Gaurav Kesharwani
Faculty of Pharmacy
VNS Group of Institutions, Rajiv Gandhi Proudyogiki Vishwavidyalaya
Bhopal, Madhya Pradesh
India

Gunjan Kalyani
Columbia Institute of Pharmacy, Chhattisgarh Swami Vivekanand Technical University
Raipur, Chhattisgarh
India

Jasaswi Ray
Department of Pharmaceutical Analysis
College of Pharmaceutical Sciences, Biju Patnaik University of Technology
Puri, Odisha
India

Jitendra Patel
Department of Pharmacognosy
Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education (Deemed to be University)
Wardha, Maharashtra
India

Lokkanya Dewangan
Department of Chemistry
Shri Shankaracharya Institute of Pharmaceutical Sciences and Research, Shri Shankaracharya Professional University
Bhilai, Chhattisgarh
India

Monika Bhairam
Columbia Institute of Pharmacy, Chhattisgarh Swami Vivekanand Technical University
Raipur, Chhattisgarh
India

Nimisha Jain
Institute of Pharmacy, Rabindranath Tagore University
Bhojpur, Madhya Pradesh
India

Nishant Sudhir Jain
Department of Pharmacy
Guru Ghasidas Vishwavidyalaya
Bilaspur, Chhattisgarh
India

Pranali Mishra
Swami Vivekanand College of Pharmacy, Rajiv Gandhi Proudyogiki Vishwavidyalaya
Bhopal, Madhya Pradesh
India

Rajashree Mohanty
Department of Pharmaceutical Analysis
College of Pharmaceutical Sciences, Biju Patnaik University of Technology
Puri, Odisha
India

Richa Shrivastava
Department of Chemistry
Govt. Naveen Girls College, Sant Gahira Guru University
Baikunthpur, Chhattisgarh
India

Rohini Armo
Department of Pharmachemistry
Shri Rawatpura Sarkar Institute of Pharmacy, Chhattisgarh Swami Vivekanand Technical University
Kumhari, Chhattisgarh
India

Rishi Paliwal
Nanomedicine and Bioengineering Research Laboratory, Department of Pharmacy
Indira Gandhi National tribal University
Amarkantak, Madhya Pradesh
India

S Prakash Rao
Department of Pharmacognosy
Shri Rawatpura Sarkar Institute of Pharmacy, Chhattisgarh Swami Vivekanand Technical University
Kumhari, Chhattisgarh
India

Sandhya Mishra
Columbia Institute of Pharmacy, Chhattisgarh Swami Vivekanand Technical University
Raipur, Chhattisgarh
India

Shakti Ketan Prusty
Department of Pharmacology
School of Pharmaceutical Sciences, Siksha'o' Anushandhan Deemed to be University
Bhubaneswar, Odisha
India

Smriti Dewangan
Amity Institute of Pharmacy, Amity University Chhattisgarh
Raipur, Chhattisgarh
India

Sonika Prajapati
Institute of Pharmacy
Rabindranath Tagore University
Bhojpur, Madhya Pradesh
India

Suchismita Acharya
Department of Chemistry, School of Applied Sciences
Centurion University of Technology & Management
Jatni, Odisha
India

Subas Chandra Dinda
School of Pharmacy
The Neotia University
Jhinga, West Bengal
India

Surendra Kumar Saraf
Department of Pharmaceutical Sciences
Columbia Institute of Pharmacy, Chhattisgarh Swami Vivekanand Technical University
Raipur, Chhattisgarh
India

Tripti Sharma
Department of Pharmaceutical Chemistry
Bomaby College of Pharmacy, University of Mumbai
Mumbai, Maharashtra
India

Varsha Rawat
Department of Pharmaceutics
Shri Rawatpura Sarkar Institute of Pharmacy, Chhattisgarh Swami Vivekanand Technical University
Kumhari, Chhattisgarh
India

Vaibhav Maturkar
Department of Pharmacy
Guru Ghasidas Vishwavidyalaya
Bilaspur, Chhattisgarh
India

Venu Anand Das Vaishnav
Department of Pharmacy
Guru Ghasidas Vishwavidyalaya
Bilaspur, Chhattisgarh
India

Vidya Kakad
Faculty of Pharmacy
Chhatrapati Shivaji Maharaj University
Navi Mumbai, Maharashtra
India

Vinita Goti
Department of Pharmacology
Shri Rawatpura Sarkar Institute of Pharmacy, Chhattisgarh Swami Vivekanand Technical University
Kumhari, Chhattisgarh
India

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