Editors: Naresh Kumar Rangra, Amandeep Singh, Rohit Bhatia

Drug Repurposing for Antivirals

eBook: US $89 Special Offer (PDF + Printed Copy): US $143
Printed Copy: US $98
Library License: US $356
ISBN: 979-8-89881-115-0 (Print)
ISBN: 979-8-89881-114-3 (Online)
Year of Publication: 2025
DOI: 10.2174/97988988111431250101

Introduction

Drug Repurposing for Antivirals is a timely volume bridging pharmacology, virology, and computational science to present a cohesive understanding of the scientific and translational potential of drug repurposing in antiviral therapy with innovative strategies of finding new antiviral applications for existing drugs, an approach that shortens development timelines, reduces costs, and accelerates clinical deployment.

The book covers core concepts, from historical successes to modern applications in combating viral diseases. It explores computational screening, molecular docking, and AI-driven tools for identifying candidate molecules; experimental validation methods; and real-world case studies involving influenza, SARS-CoV-2, HIV, and hepatitis viruses. Special focus is given to host-targeted antivirals, broad-spectrum agents, and strategies to counter viral resistance. Regulatory aspects, challenges, and future directions for integrating repurposed antivirals into clinical practice are also discussed.

Key Features

  • - Integrates theory, methodology, and real-world case studies.
  • - Covers both computational and experimental approaches.
  • - Highlights implications for pandemic preparedness and rapid-response drug discovery.
  • - Includes contributions from leading experts in virology, medicinal chemistry, and pharmacology.

Target Readership:

Environmental scientists, biotechnologists, microbiologists, and researchers seeking innovative molecular and bioremediation techniques to restore ecological balance.

Preface

In the ever-evolving landscape of medical science, the quest for effective antiviral therapies stands as a paramount challenge and an imperative for the well-being of humanity. As we navigate the complexities of infectious diseases, the concept of repurposing existing drugs emerges as a beacon of promise—a testament to our capacity for innovation and adaptability.

This preface serves as a contemplative gateway into the realm of drug repurposing for antiviral therapy, a subject that bridges the realms of discovery, translational research, and clinical application. As we embark on this exploration, it is essential to acknowledge the multifaceted nature of our endeavour.

The backdrop of drug repurposing is painted against the canvas of scientific serendipity and the constant evolution of our understanding of pharmacology. It is a narrative that celebrates the unexpected, where the drugs that are developed for one purpose reveal an unsuspected potential in the realm of antiviral defence. This approach is emblematic of our capacity to extract novel solutions from the familiar, propelling us toward faster, more cost-effective responses to viral threats.

The purpose of this exploration goes beyond the immediate need for antiviral interventions. It is a strategic response that leverages the wealth of pharmacological knowledge accrued over decades. As we delve into the diverse mechanisms of action inherent in repurposed drugs, we anticipate not only immediate solutions to pressing health challenges but also the seeds of innovation that may blossom into broader therapeutic strategies.

This compendium is a collaborative effort that brings together insights from researchers, clinicians, and pharmaceutical pioneers. It seeks to unravel the potential of drug repurposing by examining the nuances of molecular interactions, clinical trials, and the intricate dance between viruses and therapeutic agents. Through the chapters that follow, we embark on a journey that not only sheds light on the present state of antiviral repurposing but also looks forward to the untapped possibilities that lie on the horizon.

As we turn these pages, may we find inspiration in the resilience of scientific inquiry, the ingenuity of drug repurposing, and the collective commitment to safeguarding public health. May this compendium serve as both a guide and a catalyst for further exploration, fostering a community of thinkers and doers dedicated to advancing the frontiers of antiviral therapy.

Naresh Kumar Rangra
Chitkara University School of Pharmacy
Chitkara University, Himachal Pradesh
India

Amandeep Singh
Department of Pharmaceutics
ISF College of Pharmacy, Moga, Punjab
India

&


Rohit Bhatia
Department of Pharmaceutical Chemistry
Chitkara College of Pharmacy, Rajpura, Punjab
India