Editors: Naresh Kumar Rangra, Amandeep Singh, Rohit Bhatia

Drug Repurposing for Antivirals

eBook: US $89 Special Offer (PDF + Printed Copy): US $143
Printed Copy: US $98
Library License: US $356
ISBN: 979-8-89881-115-0 (Print)
ISBN: 979-8-89881-114-3 (Online)
Year of Publication: 2025
DOI: 10.2174/97988988111431250101

Introduction

Drug Repurposing for Antivirals is a timely volume bridging pharmacology, virology, and computational science to present a cohesive understanding of the scientific and translational potential of drug repurposing in antiviral therapy with innovative strategies of finding new antiviral applications for existing drugs, an approach that shortens development timelines, reduces costs, and accelerates clinical deployment.

The book covers core concepts, from historical successes to modern applications in combating viral diseases. It explores computational screening, molecular docking, and AI-driven tools for identifying candidate molecules; experimental validation methods; and real-world case studies involving influenza, SARS-CoV-2, HIV, and hepatitis viruses. Special focus is given to host-targeted antivirals, broad-spectrum agents, and strategies to counter viral resistance. Regulatory aspects, challenges, and future directions for integrating repurposed antivirals into clinical practice are also discussed.

Key Features

  • - Integrates theory, methodology, and real-world case studies.
  • - Covers both computational and experimental approaches.
  • - Highlights implications for pandemic preparedness and rapid-response drug discovery.
  • - Includes contributions from leading experts in virology, medicinal chemistry, and pharmacology.

Target Readership:

Environmental scientists, biotechnologists, microbiologists, and researchers seeking innovative molecular and bioremediation techniques to restore ecological balance.

Preface

- Pp. i
Naresh Kumar Rangra, Amandeep Singh, Rohit Bhatia
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List of Contributors

- Pp. ii-iv (3)

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Introduction to Drug Repurposing for Antiviral Therapy

- Pp. 1-17 (17)
Harpreet Singh*, Bhuvnesh Kumar Singh, Kanupriya Chauhan, Geetanjali Mehara, Pradeep Singh, Sourbh Suren Garg

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Case Studies in Antiviral Drug Repurposing

- Pp. 18-46 (29)
Priyanka, Komal Parmar, Sharma Vedika Vijaypal, Rimmi Rawat, Himanshu Chaudhry*, Ravi Pratap Singh, Kankan Majumdar

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In-silico and Target-based Approaches for Drug Repurposing in Antiviral Therapy

- Pp. 47-77 (31)
Pankaj Dagur, Nisha Singh, Rahul Ghosh, Manik Ghosh*

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In-vitro Methods for Drug Repurposing in AntiViral Therapy

- Pp. 78-120 (43)
Narendra Vijay Tirpude, Anamika Sharma*

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In-vivo Methods for Drug Repurposing in Antiviral Therapy

- Pp. 121-153 (33)
Anamika Sharma, Narendra Vijay Tirpude*

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Applications of AI/ML in Drug Repurposing for Antiviral Therapy

- Pp. 154-200 (47)
Chayanta Sen, Pankaj Paul, Ankit Tiwari, Durbadal Ojha, Ahana Hazra, Nahid Zaman, Khubaib Akhtar Khan, Pijush Kanti Shit, Amalesh Samanta*

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Nano-Formulations of Repurposed Drugs for Antiviral Therapy

- Pp. 201-221 (21)
Sandeep Rathor*, Nikita Dhiman, Khalid Basir Mir

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Pharmacoeconomics of Repurposed Drugs for Antiviral Therapy

- Pp. 222-252 (31)
Rohit Bhardwaj, Rahul Singh, Satyendra Kumar Rajput

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Clinical Trial of Repurposed Drugs for Antiviral Therapy

- Pp. 253-271 (19)
Pankaj Jinta, Chetna Jhagta, Shivani Rana, Priyanka Nagu, Vijay Kumar Bhardwaj, Vineet Mehta*

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Pitfalls of Drug Repurposing and Lesson Learned from COVID-19

- Pp. 272-300 (29)
Sandeep Purkar, Ramanlal Kachave*, Shilpa Harak, Dhanashri Mali, Deepali Bhandari

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Subject Index

- Pp. 301-303 (3)
Naresh Kumar Rangra, Amandeep Singh, Rohit Bhatia
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